Professor Mulder heads the Computational Biology Group (CBIO) at the University of Cape Town (UCT) ( She graduated with a Bachelor degree, cum laude, in Chemistry and Microbiology, and a first class Honours degree in Microbiology, followed by a PhD in Medical Microbiology. She then spent over 8 years at the European Bioinformatics Institute (EBI) in Cambridge, moving into the area of bioinformatics. At the EBI she was a Team Leader, responsible for development of InterPro and the Gene Ontology Annotation Project. InterPro was one of the most heavily used Bioinformatics resources at the Institute. At UCT, A/Prof Mulder works in the area of bioinformatics of infectious diseases, including pathogen and host genomics and biological networks, human variation and disease association studies. She heads the CBIO group, which consists of over 20 staff and students. The group provides bioinformatics support and training for postgraduate students and local researchers. A/Prof Mulder convenes an Honours programme in Bioinformatics, and organises an annual national training course for postgraduate students.

Internationally, she is involved in capacity development in Africa, as leader of a large NIH-funded consortium, H3ABioNet, to build a Pan-African Bioinformatics network for H3Africa, and through her position as President of the African Society for Bioinformatics and Computational Biology. H3ABioNet is a network of over 30 institutions in 15 African countries and 2 in the USA, which aims to build bioinformatics capacity for genomics research on the continent and develop the infrastructure for managing large-scale genomics data from H3Africa projects. A/Prof Mulder is a member of the ELIXIR Scientific Advisory Board, which includes the major bioinformatics stakeholders in Europe, and is a founding member of the Global Organisation for Bioinformatics Learning, Education & Training (GOBLET). She is on the executive committee of the African Institute for Mathematical Sciences, as well as a number of review and advisory boards.